- ¥540 - 940
- Solarbio
- 北京
- IF1400
- 2026年08月13日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
相关阅读
AI 赋能培养基定制开发：CHO 培养基是如何实现产量提升Cytoscape 教程来了！快速实现顶刊同款通路网络图五大应用案例：Mustang Q 膜层析应用全解析1 个小工具，一次性搞定流程图、质粒图谱和信号通路图- 详细信息
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Flavoxate Hydrochloride
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- CAS号：
3717-88-2
- 规格：
100mg/500mg
| 规格： | 100mg | 产品价格： | ¥540.00 |
|---|---|---|---|
| 规格： | 500mg | 产品价格： | ¥940.00 |
| CAS | 3717-88-2 |
| 中文名称 | 盐酸黄酮哌酯 |
| 英文名称 | Flavoxate Hydrochloride |
| 别名 | NSC-114649;DW61;Rec-7-0040 |
| 分子式 | C24H26ClNO4 |
| 分子量 | 427.92 |
| 规格 | 100mg ; 500mg |
| 溶解性 | Soluble in Water/DMSO(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| 运输条件 | 冷藏运输 |
| EC | EINECS 223-066-4 |
| MDL | MFCD00072099 |
| SMILES | CC1=C(OC2=C(C1=O)C=CC=C2C(=O)OCCN3CCCCC3)C4=CC=CC=C4.Cl |
| InChIKey | XOEVKNFZUQEERE-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2，4-5，8-12H，3，6-7，13-16H2，1H3;1H |
| PubChem CID | 441345 |
| 靶点 | mAChR |
| 通路 | Neuronal Signaling;GPCR & G Protein |
| 背景说明 | 是一种毒蕈碱受体AChR拮抗剂。 |
| 生物活性 | Flavoxate Hydrochloride 是毒蕈碱类 mAChR 拮抗剂，可用于膀胱过度活动症（OAB）和下尿路感染的研究。[1-4] |
| In Vitro | Flavoxate(>10 μM)suppressed carbachol- and calcium ion(Ca2+)-induced contractions of isolated detrusor strips in a noncompetitive and a competitive manner.[1] Flavoxate(10(-8)-10(-5)M)inhibited cAMP formation in a concentration-dependent manner，an action which was completely abolished by pretreating the membranes with pertussis toxin(PTX).[2] In human detrusor myocytes，flavoxate inhibited the peak amplitude of voltage-dependent nifedipine-sensitive inward Ba(2+)currents in a voltage- and concentration-dependent manner(K(i)= 10 microM)，and shifted the steady-state inactivation curve of Ba(2+)currents to the left at a holding potential of -90 mV.[3] Flavoxate piperine hydrochloride inhibited voltage-dependent nifedipine-sensitive Ba2+ inward currents(I Ba)in human forcing myocytes at 30 and 37 degrees Celsius，with instrumental Ki values of 5.1 micromolar and 4.6 micromolar，respectively.[4] |
| In Vivo | Intravenous flavoxate(10 mg/kg)suppressed both initial phasic，and later tonic，bladder contractions induced by electrical stimulation of the distal end of the pelvic nerve. When administered intracerebroventricularly(50-200 μg)or intrathecally(100-200 μg)，it abolished isovolumetric rhythmic bladder contractions. [1] Flavoxate(3 mg/kg，i.v.)completely abolished rhythmic bladder contractions in vehicle-pretreated rats，but not in PTX-pretreated rats.[2] |
| 数据来源文献 | [1]. Kimura Y，et al. Mechanisms of the suppression of the bladder activity by flavoxate. Int J Urol. 1996 May;3(3):218-27. [2]. Oka M，et al. Brain pertussis toxin-sensitive G proteins are involved in the flavoxate hydrochloride-induced suppression of the micturition reflex in rats. Brain Res. 1996 Jul 15;727(1-2):91-8. [3]. Tomoda T，et al. The effects of flavoxate hydrochloride on voltage-dependent L-type Ca2+ currents in human urinary bladder. Br J Pharmacol. 2005 Sep;146(1):25-32. [4]. Tomoda T，et al. Effects of flavoxate hydrochloride on voltage-dependent Ba2+ currents in human detrusor myocytes at different experimental temperatures. Naunyn Schmiedebergs Arch Pharmacol. 2007 Nov;376(3):195-203. |
| 单位 | 瓶 |
| 表格1 | |*|1mg|5mg|10mg|$$|1mM|2.3369mL|11.6844mL|23.3689mL|$$|5mM|0.4674mL|2.3369mL|4.6738mL|$$|10mM|0.2337mL|1.1684mL|2.3369mL| |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
盐酸黄酮哌酯
¥540 - 940
