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- 详细信息
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Flavoxate Hydrochloride
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
3717-88-2
- 规格：
500mg/100mg
| 规格： | 500mg | 产品价格： | ￥940.0 |
|---|---|---|---|
| 规格： | 100mg | 产品价格： | ￥540.0 |
| 基本信息 | |
| CAS | No.3717-88-2 |
| 中文名称 | 盐酸黄酮哌酯 |
| 英文名称 | Flavoxate Hydrochloride |
| 别名 | NSC-114649;DW61;Rec-7-0040 |
| 分子式 | C24H26ClNO4 |
| 分子量 | 427.92 |
| 溶解性 | Soluble in Water/DMSO(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 223-066-4 |
| MDL | MFCD00072099 |
| SMILES | CC1=C(OC2=C(C1=O)C=CC=C2C(=O)OCCN3CCCCC3)C4=CC=CC=C4.Cl |
| InChIKey | XOEVKNFZUQEERE-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2，4-5，8-12H，3，6-7，13-16H2，1H3;1H |
| PubChem CID | 441345 |
| 靶点 | mAChR |
| 通路 | Neuronal Signaling;GPCR & G Protein |
| 背景说明 | 是一种毒蕈碱受体AChR拮抗剂。 |
| 生物活性 | Flavoxate Hydrochloride 是毒蕈碱类 mAChR 拮抗剂，可用于膀胱过度活动症（OAB）和下尿路感染的研究。[1-4] |
| In Vitro | Flavoxate(>10 μM)suppressed carbachol- and calcium ion(Ca2+)-induced contractions of isolated detrusor strips in a noncompetitive and a competitive manner.[1] Flavoxate(10(-8)-10(-5)M)inhibited cAMP formation in a concentration-dependent manner，an action which was completely abolished by pretreating the membranes with pertussis toxin(PTX).[2] In human detrusor myocytes，flavoxate inhibited the peak amplitude of voltage-dependent nifedipine-sensitive inward Ba(2+)currents in a voltage- and concentration-dependent manner(K(i)= 10 microM)，and shifted the steady-state inactivation curve of Ba(2+)currents to the left at a holding potential of -90 mV.[3] Flavoxate piperine hydrochloride inhibited voltage-dependent nifedipine-sensitive Ba2+ inward currents(I Ba)in human forcing myocytes at 30 and 37 degrees Celsius，with instrumental Ki values of 5.1 micromolar and 4.6 micromolar，respectively.[4] |
| 细胞实验 | Intravenous flavoxate(10 mg/kg)suppressed both initial phasic，and later tonic，bladder contractions induced by electrical stimulation of the distal end of the pelvic nerve. When administered intracerebroventricularly(50-200 μg)or intrathecally(100-200 μg)，it abolished isovolumetric rhythmic bladder contractions. [1] Flavoxate(3 mg/kg，i.v.)completely abolished rhythmic bladder contractions in vehicle-pretreated rats，but not in PTX-pretreated rats.[2] |
| 数据来源文献 | [1]. Kimura Y，et al. Mechanisms of the suppression of the bladder activity by flavoxate. Int J Urol. 1996 May;3(3):218-27. [2]. Oka M，et al. Brain pertussis toxin-sensitive G proteins are involved in the flavoxate hydrochloride-induced suppression of the micturition reflex in rats. Brain Res. 1996 Jul 15;727(1-2):91-8. [3]. Tomoda T，et al. The effects of flavoxate hydrochloride on voltage-dependent L-type Ca2+ currents in human urinary bladder. Br J Pharmacol. 2005 Sep;146(1):25-32. [4]. Tomoda T，et al. Effects of flavoxate hydrochloride on voltage-dependent Ba2+ currents in human detrusor myocytes at different experimental temperatures. Naunyn Schmiedebergs Arch Pharmacol. 2007 Nov;376(3):195-203. |
| 单位 | 瓶 |
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￥540 - 940
