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- 详细信息
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Homatropine Bromide
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
51-56-9
- 规格：
500mg
| 基本信息 | |
| CAS | No.51-56-9 |
| 中文名称 | HBR后马托品 |
| 英文名称 | Homatropine Bromide |
| 别名 | Homatropine hydrobromide |
| 分子式 | C16H22BrNO3 |
| 分子量 | 356.25 |
| 溶解性 | Soluble in Water/DMSO(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-105-3 |
| MDL | MFCD00012676 |
| 靶点 | mAChR |
| 通路 | Neuronal Signaling;GPCR & G Protein |
| 背景说明 | 是一种毒蕈碱受体 (muscarinic acetylcholine receptor) 拮抗剂。 |
| 生物活性 | Homatropine Bromide 是一种毒蕈碱受体AChR拮抗剂，可用作抗胆碱剂。[1-3] |
| 细胞实验 | In the guinea-pig left atrium，in the presence of hexamethonium(0.1-3 mM)，the muscarinic receptor blocking activity of homatropine bromide(20 microM)appears to be reduced.[1] In guinea-pig atria and rat stomach fundus，homatropine bromide had similar affinities for muscarinic receptors in stomach(pA2 = 7.13)and for those in atria mediating force(pA2 = 7.21)and rate(pA2 = 7.07)responses.[2] Homatropine bromide was administered to rats by intramuscular injection，oral gavage and rectal suppository. Plasma concentration were measured over the subsequent 12 h. Peak plasma concentrations were higher and achieved more rapidly after rectal administration than by the other routes whether homatropine bromide was administered in a water-soluble suppository base or in aqueous solution.[3] |
| 数据来源文献 | [1]. Leung E，et al. Modification by hexamethonium of the muscarinic receptors blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig. Eur J Pharmacol. 1982 May 7;80(1):11-7. [2]. Gilani SA，et al. Interaction of himbacine with carbachol at muscarinic receptors of heart and smooth muscle. Arch Int Pharmacodyn Ther. 1987 Nov;290(1):46-53. [3]. Cramer MB，et al. Rectal absorption of homatropine [14C]methylbromide in the rat. J Pharm Pharmacol. 1978 May;30(5):284-6. |
| 单位 | 瓶 |
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