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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Piracetam
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
7491-74-9
- 规格：
500mg/1g/5g
| 规格： | 500mg | 产品价格： | ￥390.0 |
|---|---|---|---|
| 规格： | 1g | 产品价格： | ￥502.0 |
| 规格： | 5g | 产品价格： | ￥790.0 |
| 基本信息 | |
| CAS | No.7491-74-9 |
| 中文名称 | 吡拉西坦 |
| 英文名称 | Piracetam |
| 别名 | UCB-6215 |
| 分子式 | C6H10N2O2 |
| 分子量 | 142.16 |
| 溶解性 | Soluble in Water/DMSO ≥5mg/mL |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 231-312-7 |
| MDL | MFCD00079246 |
| SMILES | C1CC(=O)N(C1)CC(=O)N |
| InChIKey | GMZVRMREEHBGGF-UHFFFAOYSA-N |
| InChI | InChI=1S/C6H10N2O2/c7-5(9)4-8-3-1-2-6(8)10/h1-4H2，(H2，7，9) |
| PubChem CID | 4843 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | 是GABA的环状衍生物，可作用于多种认知障碍的相关研究。 |
| 生物活性 | Piracetam 是神经递质γ-氨基丁酸（GABA）的环状衍生物，可用于治疗多种认知障碍。[1-3] |
| In Vitro | Fluorescence studies and 31P and 2H NMR spectroscopy have shown that piracetam was able to significantly decrease the fusogenic and destabilising effect of Abeta 29-42，in a concentration-dependent manner.[1] In vitro preincubation of brain membranes of aged mice with piracetam(0.1-1.0 mmol/L)enhanced membrane fluidity，as indicated by decreased anisotropy of the membrane-bound fluorescence probe 1，6-diphenyl-1，3，5-hexatriene(DPH).[2] |
| 细胞实验 | Chronic treatment of young and aged rats with piracetam(300 mg/kg once daily)significantly increased membrane fluidity in some brain regions of the aged animals，but had no measurable effect on membrane fluidity in the young rats.[2] Piracetam treatment(300 mg/kg daily for 6 weeks)improved active avoidance learning in the aged rats only and elevated membrane fluidity in all brain regions except the cerebellum in the aged animals.[3] |
| 数据来源文献 | [1]. Mingeot-Leclercq MP，et al. Piracetam inhibits the lipid-destabilising effect of the amyloid peptide Abeta C-terminal fragment. Biochim Biophys Acta. 2003 Jan 10;1609(1):28-38. [2]. Müller WE，et al. Effects of piracetam on membrane fluidity in the aged mouse，rat，and human brain. Biochem Pharmacol. 1997 Jan 24;53(2):135-40. [3]. Scheuer K，et al. Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain. Pharmacopsychiatry. 1999 Mar;32 Suppl 1:10-6. |
| 单位 | 瓶 |
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文献和实验_ChIP_method.html Chromatin IP Method, ChIP buffers, Notes on ChIP Method, Quantative PCR using 32P dCTP. Hahn Lab. ChIP Assay Protocol PDF - /attach/2008/2008-02-01/2B/2B6C4EA25F257424710A50E83CB2F380.pdf Formaldehyde cross-linking
2F+DwTquooTcizAj6Sh40arj1e+iWJ2ispgsbT801bWi9OaaVDQ0u7N9Rf22Q7je3ypEkT/aXtAx/4gHh20RbetchuWXizve3YY/3L0LGHHqt8Cva+97zf/vEfvyYb4imWXpTxLz8m4rvgjodswc3X26Xnn2o3LbjZPv/Fv5GGuGa33/ZzO2n2HD17NAEWeUXwmQh44uy32U+uutL+69e+6jjedfsddvSxx3m8xNNFQ67wipqQKHyESZ35
[资源] 所有的看家基因(housekeeping genes)列表+引物设计服务
, H+ transporting, lysosomal interacting protein 1 (ATP6IP1), mRNA 1089 NM_003526 Homo sapiens H2B histone family, member L (H2BFL), mRNA 2232 NM_004718 Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 2 like (COX7A2L), nuclear gene
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