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- 详细信息
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Telbivudine
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
3424-98-4
- 规格：
100mg/50mg/5mg/10mg
| 规格： | 100mg | 产品价格： | ￥2390.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥1440.0 |
| 规格： | 5mg | 产品价格： | ￥340.0 |
| 规格： | 10mg | 产品价格： | ￥540.0 |
| 基本信息 | |
| CAS | No.3424-98-4 |
| 中文名称 | 替比夫定 |
| 英文名称 | Telbivudine |
| 别名 | L-Thymidine;NV 02B;Epavudine |
| 分子式 | C10H14N2O5 |
| 分子量 | 242.23 |
| 溶解性 | Soluble in Water/DMSO(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL | MFCD02683612 |
| SMILES | CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O |
| InChIKey | IQFYYKKMVGJFEH-CSMHCCOUSA-N |
| InChI | InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3，6-8，13-14H，2，4H2，1H3，(H，11，15，16)/t6-，7+，8+/m1/s1 |
| PubChem CID | 159269 |
| 靶点 | HBV |
| 通路 | Anti-infection |
| 背景说明 | Telbivudine是一种HBV逆转录酶抑制剂，可用于乙型肝炎感染的相关研究。 |
| 生物活性 | Telbivudine 是一种口服活性胸苷核苷类似物，是乙型肝炎病毒（HBV）复制的强效抗病毒抑制剂。[1] |
| In Vitro | Telbivudine had no effect on MHV-3 replication in macrophages. However，the production of tumour necrosis factor-alpha and interleukin-12 was increased significantly in MHV-3-induced macrophages treated with telbivudine.[2]Telbivudine was not active against HBV strains bearing lamivudine mutations L180M/M204V/I but remained active against the M204V single mutant in vitro. Against HBV cell lines expressing adefovir resistance mutations N236T and A181V，or the A194T mutant associated with resistance to tenofovir，telbivudine remained active as shown by respective fold-changes of 0.5(N236T)and 1.0(A181V and A194T). [3] |
| 细胞实验 | Telbivudine was well tolerated in rats and in monkeys following single oral doses up to 2，000 mg/kg/day. Except for equivocal axonopathic findings in monkeys and occasional incidences of emesis，soft feces，and minor changes in body weight and food consumption，there was no target organ toxicity observed in mice，rats，or monkeys following oral administration for up to 3，6，or 9 months，respectively，at doses up to 3，000 mg/kg/day. [1]Serum levels of interferon-gamma were elevated significantly after telbivudine treatment in MHV-3-infected C3H mice. In contrast，serum interleukin-4 levels were decreased significantly. Furthermore，telbivudine treatment enhanced the ability of T cells to undergo proliferation and secrete cytokines but did not affect cytotoxicity of infected hepatocytes. Telbivudine treatment suppressed programmed death ligand 1 expression on T cells. [2] |
| 数据来源文献 | [1]. Bridges EG，et al. Nonclinical safety profile of telbivudine，a novel potent antiviral agent for treatment of hepatitis B. Antimicrob Agents Chemother. 2008 Jul;52(7):2521-8. doi: 10.1128/AAC.00029-08. Epub 2008 May 12. [2]. Wu ZG，et al. Telbivudine preserves T-helper 1 cytokine production and downregulates programmed death ligand 1 in a mouse model of viral hepatitis. J Viral Hepat. 2010 Mar;17 Suppl 1(Suppl 1):24-33. [3]. Seifer M，et al. Telbivudine，a nucleoside analog inhibitor of HBV polymerase，has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir. Antiviral Res. 2009 Feb;81(2):147-55. |
| 单位 | 瓶 |
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￥340 - 2390
