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- 详细信息
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Sulfanilamide
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
63-74-1
- 规格：
10g/5g/500mg
| 规格： | 10g | 产品价格： | ￥890.0 |
|---|---|---|---|
| 规格： | 5g | 产品价格： | ￥590.0 |
| 规格： | 500mg | 产品价格： | ￥390.0 |
| 基本信息 | |
| CAS | No.63-74-1 |
| 中文名称 | 结晶磺胺 |
| 英文名称 | Sulfanilamide |
| 别名 | 磺胺;UK-124 |
| 分子式 | C6H8N2O2S |
| 分子量 | 172.2 |
| 溶解性 | Soluble in DMSO(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-563-4 |
| MDL | MFCD00007939 |
| SMILES | C1=CC(=CC=C1N)S(=O)(=O)N |
| InChIKey | FDDDEECHVMSUSB-UHFFFAOYSA-N |
| InChI | InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8，9)10/h1-4H，7H2，(H2，8，9，10) |
| PubChem CID | 5333 |
| 靶点 | Bacterial |
| 通路 | Anti-infection |
| 背景说明 | Sulfanilamide是细菌酶中二氢喋呤合成的竞争性抑制剂。 |
| 生物活性 | Sulfanilamide 是细菌酶中二氢喋呤合成的适度竞争性抑制剂，是一种有效的口服磺胺类抗生素，是磺胺甲恶唑生物降解的主要中间体，可预防卡氏肺孢子虫和肺炎病菌感染。[1-4] |
| In Vitro | At the initial sulfanilamide concentration of 100 μg/L，nearly half of the antibiotic could be removed by acclimated microbial populations after 1 week of incubation，and an average removal rate of 78.3 % could be achieved in 4 weeks. Sulfanilamide biodegradation could be enhanced by a temperature rise and the presence of external carbon or nitrogen sources.Firmicutes and Bacteroidetes(mainly represented by classes Bacilli and Flavobacteriia)dominated the sulfanilamide-degrading bacterial community.[1] |
| 细胞实验 | Albino mice inoculated intranasally or intraperitoneally with 51. pneumoniae，strain 444. Sulfadimesin and domian，2 sulfanilamides of short action served as the control. The drugs were administered orally in a dose of 500 mg/kg daily for 5 days. High efficacy of the sulfanilamide depots in the treatment of the 51. pneumoniae infected mice and low activity of the short-action drugs were shown.High efficacy of the sulfanilamide depots in the treatment of the 51. pneumoniae infected mice and low activity of the short-action drugs were shown，which was confirmed by the data of the pathomorphological investigation in experimental pneumonia.[2]With the immunosuppressed rat model，P. carinii infection was prevented in all animals(100%)receiving 100 mg of sulfanilamide per kg per day. [3] |
| 数据来源文献 | [1]. Liao X，et al. Antibiotic sulfanilamide biodegradation by acclimated microbial populations. Appl Microbiol Biotechnol. 2016 Mar;100(5):2439-47. [2]. Pade skaia EN，et al. Sravnitel'naia aktivnost' depo-sul'fanilamidov pri éksperimental'no infektsii myshe ，vyzvanno K1. pneumoniae [Comparative activity of depot sulfanilamides in experimental infection in mice caused by K1. pneumoniae]. Antibiotiki. 1980 Mar;25(3):193-8. [3]. Hughes WT，et al. Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1996 Apr;40(4):962-5. [4]. McCullough JL，et al. Inhibition of dihydropteroate synthetase from Escherichia coli by sulfones and sulfonamides. Antimicrob Agents Chemother. 1973 Jun;3(6):665-9. |
| 单位 | 瓶 |
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IS2710 结晶磺胺 抗感染 索莱宝
￥390 - 890
