- ￥1668
- abinScience
- China
- HB517014
- 2026年03月03日
- ELISA, IHC, WB
- Rabbit
- Human, Bovine, Rat, Mouse
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- 文献和实验
- 技术资料
- 免疫原：
Rabbit
- 亚型：
IgG
- 形态：
Liquid
- 保存条件：
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
Human, Bovine, Rat, Mouse
- 保质期：
1 year
- 抗原来源：
Rabbit
- 目录编号：
HB517014
- 级别：
科研级别
- 库存：
999
- 供应商：
abinScience
- 宿主：
Rabbit
- 应用范围：
ELISA, IHC, WB
- 浓度：
1mg/mL
- 靶点：
Transcription factor HES-1; Class B basic helix-loop-helix protein 39; bHLHb39; Hairy and enhancer of split 1; Hairy homolog; Hairy-like protein; hHL; HES1; BHLHB39; HL; HRY
- 抗体英文名：
Anti-HES1 Polyclonal Antibody
- 抗体名：
Anti-HES1 Polyclonal Antibody
- 规格：
100ul
| Product name | Anti-HES1 Polyclonal Antibody |
|---|---|
| Catalog No. | HB517014 |
| Host species | Rabbit |
| Species reactivity | Human, Bovine, Rat, Mouse |
| Immunogen | E. coli - derived recombinant human HES1 (Pro2-Asn280). |
| Form | Liquid |
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Purity | / |
| Clonality | Polyclonal |
| Isotype | IgG |
| Applications | ELISA, IHC, WB |
| Target | Transcription factor HES-1; Class B basic helix-loop-helix protein 39; bHLHb39; Hairy and enhancer of split 1; Hairy homolog; Hairy-like protein; hHL; HES1; BHLHB39; HL; HRY |
| Purification | Purified by antigen affinity column. |
| Endotoxin level | Please contact with the lab for this information. |
| Expression system | / |
| Accession | Q14469, Q3ZBG4, Q04666, P35428 |
| Alternative Names | / |
| Clone ID | / |
| Species | / |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
abinScience, founded in 2023 in Strasbourg, France, is committed to developing and producing high-quality life science reagents. Rooted in one of Europe’s leading hubs for scientific innovation, abinScience empowers global research through reliable, efficient experimental solutions. Guided by the vision of “Empowering Bioscience Discovery,” we support scientists worldwide in advancing the frontiers of bioscience.
Technology and Innovation
Relying on the global leading position in antibody and protein research and more than 20 years of industry experience of its parent company ProteoGenix since 2003, abinScience has inherited advanced technologies and high-quality standards. In particular, the XtenCHO™ system developed by ProteoGenix, which has two modes of transient expression and stable expression, has been widely recognized as a core technology to improve the efficiency of protein production, providing a solid foundation for abinScience's product research and development.
Product categories and application fields.
Main products.
10000+ high-activity proteins.
15000+ antibody series products:
Classic monoclonal antibody.
Monoclonal antibody
Internal control antibody, labeled antibody.
High-quality phosphorylation antibodies.
Highly specific nanobodies and small molecule antibodies.
Functional antibodies in vivo.
Low-background flow cytometry antibodies.
DNA/RNA antibodies and PEG antibodies.
1000+ reagent kit series products.
Large-scale packaging customization services: We offer personalized antibody design, protein production, molecular optimization, and experimental development services.
Application field
Infectious disease research: including viruses, superbugs, parasites, etc.
Neuroscience research: Supporting research on neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
Immunology research: Covers the research needs of immune activation, inhibition, and allergies and abnormal reactions.
Oncology research: Supporting the development of tumor biology and anti-tumor drugs.
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文献和实验• Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis., PMID:36535970
• A Single-Cell Transcriptomic Atlas of Human Skin Aging., PMID:33238152
• Modelling human hepato-biliary-pancreatic organogenesis from the foregut-midgut boundary., PMID:31554966
• The pivotal role of the Hes1/Piezo1 pathway in the pathophysiology of glucocorticoid-induced osteoporosis., PMID:39641269
• The NOTCH-HES-1 axis is involved in promoting Th22 cell differentiation., PMID:33622250
• The Notch signaling cascade in neuroblastoma: role of the basic helix-loop-helix proteins HASH-1 and HES-1., PMID:15013216
• Sirt3 promotes the autophagy of HK‑2 human proximal tubular epithelial cells via the inhibition of Notch‑1/Hes‑1 signaling., PMID:34278469
• HES1 in immunity and cancer., PMID:27066918
• Automated live-cell single-molecule tracking in enteroid monolayers reveals transcription factor dynamics probing lineage-determining function., PMID:39480809
Polyclonal Antibody Production
, if desired this is best accomplished by Protein A Affinity Chromatography. 上一篇：make an Antibody against a Peptides 下一篇：Immunization Protocol for Monoclonal Antibody Production
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
在肿瘤生长中的作用。研究发现，抑制垂体中 POMC 的表达对荷瘤小鼠没有明显的毒性，并且抑制了 LLC 肿瘤的生长，同时增强了肿瘤中 CD8+T、CD4+T、NK 和 NKT 细胞的浸润，IFN-γ 也在这些免疫细胞中表达上调（图 2 A-D）。然而，补充 α-MSH 逆转了 POMC 的表达抑制对肿瘤生长和抗肿瘤免疫的影响。采用抗 CD4 和抗 CD8 抗体处理小鼠，耗尽肿瘤中 CD4+ 和 CD8+T 细胞，结果发现也消除了敲低 POMC 对肿瘤生长抑制的作用（图 2 E）。结果说明，抑制垂体中
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