Hepcidin-25 (trifluoroacetate

一种肽类激素；与铁转运蛋白结合，诱导其内化和降解，从而增加细胞内铁水平，降低膳食铁吸收和血浆铁水平；对6.25-50µg/ml的多重耐药革兰氏阴性和革兰氏阳性细菌临床分离株具有杀菌作用；CKD患者血清中的水平升高。A peptide hormone; binds to ferroportin, inducing its internalization and degradation, which increases intracellular iron levels and decreases dietary iron absorption and plasma iron levels; bactericidal against multidrug-resistant clinical isolates of Gram-negative and Gram-positive bacteria from 6.25-50 µg/ml; levels are increased in the serum of patients with CKD.分子式C113H170N34O31S9 • XCF3COOH分子量2789.4O=C(O)C[C@H](N[H])C(N[C@]([C@H](O)C)([H])C(N[C@@H](CC1=CNC=N1)C(N[C@H](C(N2CCC[C@H]2C(N[C@@](C(N[C@@H](CSSC[C@H](N3)C(N[C@@H](CCCCN[H])C(N[C@]([C@H](O)C)([H])C(O)=O)=O)=O)C(N[C@@](C(N[C@H](C(N[C@@H](CSSC[C@H](N4)C(N[C@@H](CSSC[C@H](N5)C3=O)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCCN[H])C7=O)=O)=O)=O)=O)=O)C(N[C@@H](CSSC[C@H](N7)C(NCC(N[C@@H](CCSC)C5=O)=O)=O)C(NCC4=O)=O)=O)=O)CC8=CC=CC=C8)=O)([H])[C@@H](C)CC)=O)=O)([H])[C@@H](C)CC)=O)=O)CC9=CC=CC=C9)=O)=O)=O.OC(C(F)(F)F)=O