C53

STING激动剂；在ISG54荧光素酶报告基因检测中，10µM可激活人类野生型STING(EC50=185nM)，以及HEK293细胞中含有多态性R232、H232或HAQ的STING；在10µM时诱导分离的hMO-DC中IFN-α、IFN-β、TNF-α、CXCL10、IL-12p40和IL-6的表达；在10µM时增加hMO-DC中树突状细胞标志物CD83和CD86的表达。A STING agonist; activates human wild-type STING (EC50 = 185 nM), as well as STING containing the polymorphisms R232, H232, or HAQ in HEK293 cells in an ISG54 luciferase reporter assay at 10 µM; induces the expression of IFN-α, IFN-β, TNF-α, CXCL10, IL-12p40, and IL-6 in isolated hMO-DCs at 10 µM; increases the expression of the dendritic cell markers CD83 and CD86 in hMO-DCs at 10 µM.分子式C25H19ClF4N2O2分子量490.9O=C(C1=CC=C2C(N(CC3=C(F)C=CC=C3Cl)C(C2(C)C)=O)=C1)NCC4=C(F)C=C(F)C=C4F