DC-05

非核苷DNMT1抑制剂（IC50=10.3µM）；对DNMT1具有选择性，优于DNMT3A和DNMT3B（IC50s=>200µM），以及G9a、SUV39H1、MLL1、SET7/9和PRMT1（IC50s分别为>150、>150、>150、>150和37.1µM）；可将HCT116结肠癌细胞的增殖从2.5µM降低至10µM。A non-nucleoside DNMT1 inhibitor (IC50 = 10.3 µM); selective for DNMT1 over DNMT3A and DNMT3B (IC50s = >200 µM), as well as G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC50s = >150, >150, >150, >150, and 37.1 µM, respectively); reduces proliferation of HCT116 colon cancer cells from 2.5-10 µM.分子式C25H25N3O分子量383.5OC(CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CNCCC4=CNC5=C4C=CC=C5