KAS 08

STING激活剂（使用THP-1人单核细胞进行报告检测时EC50=0.33µM）；在cGAMP存在（而非不存在）的情况下增加IFN-β和IP-10水平；在0.31-20µM时降低CT26细胞活力；与2'3'-cGAMP结合使用时，在15mg/kg时降低CT26小鼠同源模型中的肿瘤生长。A STING activator (EC50 = 0.33 µM in a reporter assay using THP-1 human monocytes); increases IFN-β and IP-10 levels in the presence, but not absence, of cGAMP; reduces the viability of CT26 cells at 0.31-20 µM; reduces tumor growth in a CT26 mouse syngeneic model at 15 mg/kg when used in combination with 2'3'-cGAMP.分子式C24H20N4O6S分子量492.5O=C(C1=CC=C([N+]([O-])=O)C=C1)N2CCC3=CC(S(=O)(N4C(N[C@](C5=CC=CC=C5)([H])C4)=O)=O)=CC=C32