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- 爱必信(Absin)
- 中国
- abs816962
- 2025年07月20日
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- 库存：
99
- 供应商：
爱必信（上海）生物科技有限公司
- 规格：
100mg
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抑制剂描述： 产品名称：Benzocaine 产品别名：见爱必信官网 英文别名：Benzocaine 靶点：Sodium Channel CAS：94-09-7 纯度：99% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述： Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. 溶解性：DMSO 31 mg/mL (187.7 mM) 体外研究： Benzocaine blocks μ1 wild-type Na+ currents in a dose-dependent Manner. The Benzocaine concentration that inhibits 50% of Na+ currents (IC50) is estimated to be about 0.8 mM when a test potential of +30 mV is applied. The slope of the h∞ curve is also significantly reduced by benzocaine (from 6.6 to 9.9 mV). Mutation of μ1-N1584A also significantly increases the potency of Benzocaine. At 1 mM, Benzocaine blocks about 55% of wild-type Na+ current but about 95% of μ1-N1584A mutant current. Benzocaine also appears to bind more strongly to its LA receptor in the N1584A mutant than in the wild type. The inhibition of Ca2+ uptake occurres at lower Benzocaine concentration (IC50=40.3±1.2mM) than that affecting the enzymatic activity. 体内研究：A common Benzocaine-containing anesthetic is topically applied to the following species: dogs, domestic shorthair cats, Long-Evans rats, Sprague-Dawley rats, ferrets, rhesus monkeys, cynomolgus monkeys, owl monkeys, New Zealand White rabbits, miniature pigs, ICR mice, C3H mice, and C57BL/10SnJ mice. All animals, except mice and rats, receive a 2-second spray to the mucous membranes of the nasopharynx for an estimated dose of 56 mg. A 2-second spray to rodents' oral mucous membranes delivers too great a volume of fluid for these animals. The study is repeated in dogs several months later to confirm low response. Response to Benzocaine spray is observed in most animals tested, with response peaking between 15 and 30 minutes after dosing.
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文献和实验the females). We keep these males separate from females. Anesthetize the male in 0.05% benzocaine. If this is done at room temperature it can sometimes take quite a long time before the male is adequately anesthetized. We find that placing the male
mg/L 作用时间100～200min 可可巴比妥钠 水体 70～00mg/L作用时间 100～200min 二乙醚 水体 20～30mg/L作用时间 15～30min CO2 水体 >400ppm 作用时间15～20min. 注：当发现鱼麻醉后，可拿出来击头部以处死 其他方法：脊髓穿刺，TMS ，MS222（肉用鱼类不得使用TMS和MS222），Benzocaine HCl。 2、两栖类 Barbiturate注射液，静脉注射（60～100mg/kg）； Barbiturate注射
oocyte isolation Anethesize female using benzocaine - put ~5ml 6% benzocaine (stock solution in 100% ethanol) into 1L water. - leave animal until it is limp and completely
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