SABRAC

酸性神经酰胺酶抑制剂(IC50=52nM)；3µM时对酸性神经酰胺酶的选择性优于中性神经酰胺酶和半胱氨酸蛋白酶木瓜蛋白酶；抑制PC3MC细胞中的酸性神经酰胺酶(IC50=<1µM)，并诱导神经酰胺在相同细胞中的积累；5µM时完全抑制PC3MC细胞的锚定非依赖性菌落形成。An inhibitor of acid ceramidase (IC50 = 52 nM); selective for acid ceramidase over neutral ceramidase and the cysteine protease papain at 3 µM; inhibits acid ceramidase in PC3 MC cells (IC50 = <1 µM), as well as induces accumulation of ceramides in the same cells; completely inhibits anchorage-independent colony formation by PC3 MC cells at 5 µM.分子式C20H40BrNO3分子量422.4BrCC(N[C@@H](CO)[C@@H](CCCCCCCCCCCCCCC)O)=O