rac-Benpyrine

TNF-α-TNFR1蛋白质-蛋白质相互作用的抑制剂(IC50=0.109µM)；10µM时可降低L-929成纤维细胞中TNF-α诱导的细胞毒性；防止RAW 264.7巨噬细胞中NF-κB的核易位；25mg/kg时可提高LPS诱发的内毒血症小鼠模型的存活率，降低胶原诱发的关节炎和咪喹莫特诱发的牛皮癣小鼠模型的病情严重程度。An inhibitor of the TNF-α-TNFR1 protein-protein interaction (IC50 = 0.109 µM); reduces TNF-α induced cytotoxicity in L-929 fibroblasts at 10 µM; prevents nuclear translocation of NF-κB in RAW 264.7 macrophages; improves survival in a mouse model of LPS-induced endotoxemia and decreases disease severity in mouse models of collagen-induced arthritis and imiquimod-induced psoriasis at 25 mg/kg.分子式C16H16N6O分子量308.3O=C1N(CC2=CC=CC=C2)CC(NC3=NC=NC4=C3NC=N4)C1