Pulmatin

一种蒽醌糖苷；浓度为50µg/ml时可抑制PTP1B（IC50=18.34µM）和酵母及大鼠肠道α-葡萄糖苷酶；浓度为25µM时可使L6肌管中胰岛素诱导的葡萄糖转运增加255%；浓度为100mg/kg时可降低Triton WR-1339诱发的血脂异常大鼠模型中的血浆总胆固醇、磷脂、LDL、VLDL和甘油三酯水平。An anthraquinone glycoside; inhibits PTP1B (IC50 = 18.34 µM) and yeast and rat intestinal α-glucosidase at 50 µg/ml; increases insulin-induced glucose transport by 255% in L6 myotubes at 25 µM; lowers plasma levels of total cholesterol, phospholipids, LDL, VLDL, and triglycerides in a rat model of Triton WR-1339-induced dyslipidemia at 100 mg/kg.分子式C21H20O9分子量416.4O=C(C1=CC(C)=CC(O)=C12)C3=CC=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C3C2=O