3-Acetylaconitine

一种具有多种生物活性的二萜生物碱；对P388白血病细胞有细胞毒性(IC50=18.6µM)；抑制短毒素与大鼠脑突触体的结合(IC50=1.3µM)，并增加大鼠脑突触体中的游离钠和钙浓度；在100µg/kg静脉注射剂量下，可减少福尔马林诱发的炎症疼痛小鼠模型中舔爪子、弹爪和抖动。A diterpene alkaloid with diverse biological activities; cytotoxic to P388 leukemia cells (IC50 = 18.6 µM); inhibits brevetoxin binding to (IC50 = 1.3 µM), and increases free sodium and calcium concentrations in, rat brain synaptosomes; reduces paw licking, flicking, and shaking in a mouse model of formalin-induced inflammatory pain at 100 µg/kg, i.v.分子式C36H49NO12分子量687.8CO[C@@H](C[C@H]1OC(C)=O)C([C@@](C[C@@]2([C@H]3OC)O)([H])[C@H](C2([H])OC(C4=CC=CC=C4)=O)[C@@]5([C@H]3O)OC(C)=O)([C@@]6([H])[C@@]17COC)C(N(C7)CC)C5[C@@H]6OC