α-Cembrenediol

一种具有多种生物活性的二萜类化合物；可抑制TPA在Raji细胞中诱导EA-EBV（IC50=25.2μM）；可对抗植物病原菌V.mali（IC50=18mg/L）；皮肤应用（3.3µmol）可使TPA对小鼠中7,12-去甲基苯并[a]蒽诱发的乳头状瘤形成的促肿瘤作用降低53%；已在香烟烟雾冷凝物中发现。A diterpenoid with diverse biological activities; inhibits induction of EA-EBV by TPA in Raji cells (IC50 = 25.2 μM); active against the plant pathogenic fungus V. mali (IC50 = 18 mg/L); dermal application (3.3 µmol) reduces the tumor promoting effects of TPA on 7,12-demethylbenz[a]anthracene-induced papilloma formation by 53% in mice; has been found in cigarette smoke condensate.分子式C20H34O2分子量306.5CC([C@H]1/C=C/[C@@](O)(C[C@H](/C=C(CC/C=C(CC1)\C)/C)O)C)C