M04

STING激动剂；在75µM浓度下，可诱导表达野生型人类STING的HEK293T细胞中的IFN报告基因表达，但在表达HAQ人类STING变体的HEK293T细胞或小鼠RAW 264.7细胞中不诱导IFN报告基因表达；在人类PBMCs中诱导TNF-α、IL-10、IL-1β和IL-12p70的产生；在50µM浓度下，可增加表达HLA-DR、CD40、CD80和CD86的分离的人类单核细胞衍生树突状细胞的百分比，并在体外测定中增加相同细胞的T细胞交叉引发。A STING agonist; induces IFN reporter gene expression in HEK293T cells expressing wild-type human STING but not in HEK293T cells expressing the HAQ human STING variant nor in mouse RAW 264.7 cells at 75 µM; induces the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human PBMCs; increases the percentage of isolated human monocyte-derived dendritic cells expressing HLA-DR, CD40, CD80, and CD86, as well as increases T cell cross-priming of the same cells in an ex vivo assay, at 50 µM.分子式C18H24N2O4S3分子量428.6O=S(C1=CC=C(C)C=C1)(C2=C(N(C)C)SC(S(=O)(C3CCCCC3)=O)=N2)=O