6,7,4'-Trihydroxyisoflavone

大豆黄酮的活性代谢物；抑制HCT116和DLD-1结肠癌细胞的贴壁依赖性和非贴壁依赖性生长，并在12.5-100µM浓度下诱导HCT116细胞在S期和G2/M期细胞周期停滞；在40和80µM浓度下抑制3T3-L1前脂肪细胞中MDI诱导的脂肪生成；在5mg/kg浓度下逆转东莨菪碱诱导的记忆障碍并增加小鼠海马BDNF和CREB水平；预防小鼠LPS诱导的骨质流失。An active metabolite of daidzein; suppresses anchorage-dependent and -independent growth of HCT116 and DLD-1 colon cancer cells, as well as induces cell cycle arrest at the S and G2/M phases in HCT116 cells from 12.5-100 µM; inhibits MDI-induced adipogenesis in 3T3-L1 preadipocytes at 40 and 80 µM; reverses scopolamine-induced memory impairments and increases hippocampal BDNF and CREB levels in mice at 5 mg/kg; prevents LPS-induced bone loss in mice.分子式C15H10O5分子量270.2O=C1C(C2=CC=C(O)C=C2)=COC3=CC(O)=C(C=C13)O