Veratrosine

一种具有多种生物活性的甾体生物碱；浓度为8µM时，在报告试验中可抑制NIH3T3细胞中的Hh信号传导；浓度为1mg/ml时，可抑制花生四烯酸诱导的兔血小板分离聚集；浓度为0.25和2.5µmol/kg时，可诱导小鼠小脑和大脑皮层DNA损伤；浓度为1.5和4.5µmol/kg时，可降低血管紧张素II诱导的小鼠收缩压升高。A steroidal alkaloid with diverse biological activities; inhibits Hh signaling in NIH3T3 cells in a reporter assay at 8 µM; inhibits arachidonic acid-induced aggregation of isolated rabbit platelets at 1 mg/ml; induces DNA damage in the cerebellum and cerebral cortex in mice at 0.25 and 2.5 µmol/kg; decreases angiotensin II-induced increases in systolic blood pressure in mice at 1.5 and 4.5 µmol/kg.分子式C33H49NO7分子量571.7C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)([H])C5=CC=C([C@@H]([C@@]6([H])[C@@H](C[C@@H](CN6)C)O)C)C(C)=C5C3