GPR52 Comp-43

GPR52拮抗剂(IC50=0.63µM)；以浓度依赖性方式降低STHdhQ7/Q111细胞中的mHTT蛋白水平；减少由生长因子缺乏引起的HdhQ7/Q140小鼠分离的原代纹状体神经元的细胞凋亡；在5mg/kg剂量下，降低纹状体中可溶性和不溶性mHTT的水平，并增加HdhQ140亨廷顿氏病小鼠模型中转棒测试的跌倒潜伏期。A GPR52 antagonist (IC50 = 0.63 µM); reduces mHTT protein levels in STHdhQ7/Q111 cells in a concentration-dependent manner; reduces apoptosis induced by growth factor deprivation in primary striatal neurons isolated from HdhQ7/Q140 mice; decreases striatal levels of soluble and insoluble mHTT, as well as increases the latency to fall in the rotarod test, in the HdhQ140 mouse model of Huntington's disease at 5 mg/kg.分子式C15H14OS分子量242.3O=C(C1=CC=CS1)/C=C/CCC2=CC=CC=C2