NR-160

HDAC6抑制剂(IC50=0.03µM)；对HDAC6的选择性优于HDAC1、-2、-3、-4和-8（IC50s分别为5.18、2.26、8.48、55.4和14.7µM）；对七种癌细胞系具有细胞毒性（IC50s=22.5-51.8µM）；增强硼替佐米在HL-60细胞中诱导的细胞毒性以及表柔比星或柔红霉素在CCRF-HSB-2细胞中诱导的细胞毒性。An inhibitor of HDAC6 (IC50 = 0.03 µM); selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 µM, respectively); cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 µM); enhances bortezomib-induced cytotoxicity in HL-60 cells and epirubicin- or daunorubicin-induced cytotoxicity in CCRF-HSB-2 cells.分子式C25H21F3N6O3分子量510.5O=C(NO)C(C=C1)=CC=C1CN(CC2=NN=NN2CC3=CC=CC=C3)C(C4=C(C(F)(F)F)C=CC=C4)=O