DSM 265

一种抗疟药；抑制恶性疟原虫和间日疟原虫的DHODH（IC50s分别为8.9和27nM）；对恶性疟原虫和间日疟原虫的DHODH具有选择性，优于人类、兔、猪和猴的DHODH（IC50s=>41µg/ml），但可抑制食蟹猴、狗、小鼠和大鼠的DHODH（IC50s分别为0.005、11、1.1和0.82µg/ml）；抑制恶性疟原虫3D7菌株的生长（EC50=4.3nM）；降低小鼠血液中的寄生虫血症（ED90=1.5mg/kg，每天两次）。An antimalarial agent; inhibits P. falciparum and P. vivax DHODH (IC50s = 8.9 and 27 nM, respectively); selective for P. falciparum and P. vivax DHODH over human, rabbit, pig, and monkey DHODH (IC50s = >41 µg/ml) but does inhibit P. cynomolgi, dog, mouse, and rat DHODH (IC50s = 0.005, 11, 1.1, and 0.82 µg/ml, respectively); inhibits the growth of the P. falciparum strain 3D7 (EC50 = 4.3 nM); reduces blood parasitemia in mice (ED90 = 1.5 mg/kg twice per day).分子式C14H12F7N5S分子量415.3CC1=NC2=NC(C(F)(F)C)=NN2C(NC3=CC=C(C=C3)S(F)(F)(F)(F)F)=C1