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文献和实验Anti-c-erb-B-2 Ribozyme for Breast Cancer
Our laboratory has investigated the cleavage activity of an-anti-c-erb -B-2 ribozyme. The c-erb -B-2 proto-oncogene (also called HER-2/neu ) encodes a 185 kDa transmembrane tyrosine kinase-type receptor that is homologous with the epidermal
Introduction of human 14-3-3 proteins
whose members have been shown to activate tyrosine and tryptophan hydroxylases,inhibit protein kinase C and possess phospholipase A2 activity in vitro.We have isolated and analyzed a 14-3-3 protein cDNA clone (H14-3-3)from a human fetal brain cDNA library
Using Phospho‐Motif Antibodies to Determine Kinase Substrates
Manning, G., Whyte, D.B., Martinez, R., Hunter, T., and Sudarsanam, S. 2002b. The protein kinase complement of the human genome. Science 298:1912‐1934.
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