Capsiate

一种具有多种生物活性的辣椒素类似物；抑制5-25µM浓度的HUVEC中的Src以及VEGF诱导的增殖和管形成；激活表达人类通道的HEK293细胞中的TRPV1（EC50=290nM）并诱导小鼠的伤害感受行为；局部应用可减少小鼠被动皮肤过敏模型中抗原诱导的耳朵厚度增加，并降低小鼠特应性皮炎模型中的表皮厚度和嗜酸性粒细胞和肥大细胞浸润；在10mg/kg剂量下，在自由采食诱导体重增加的小鼠模型中，减少体重增加和肾周脂肪重量，并增加氧气消耗、脂肪氧化和碳水化合物氧化。A capsaicin analog with diverse biological activities; inhibits Src in, as well as VEGF-induced proliferation of and tube formation by, HUVECs from 5-25 µM; activates TRPV1 in HEK293 cells expressing the human channel (EC50 = 290 nM) and induces) nociceptive behaviors in mice; topical application reduces antigen-induced increases in ear thickness in a mouse model of passive cutaneous anaphylaxis and and decreases epidermal thickness and eosinophil and mast cell infiltration in a mouse model of atopic dermatitis; decreases body weight gain and perirenal fat weight, as well as increases oxygen consumption, fat oxidation, and carbohydrate oxidation, in a mouse model of ad libitum feeding-induced weight gain at 10 mg/kg.分子式C18H26O4分子量306.4CC(C)/C=C/CCCCC(OCC1=CC(OC)=C(C=C1)O)=O