Nanaomycin A

这是一种醌类细菌代谢产物，能够抑制多种细菌的生长（对疟原虫P.falciparum的IC₈₀值为0.0033µM）。此外，它还能抑制HCT116、A549和HL-60癌细胞的增殖，其IC₅₀值分别为0.4µM、4.1µM和0.8µM。在1µM浓度下，该化合物能够促进人诱导多能干细胞（iPS细胞）向肝芽细胞分化，特别是在确定性内胚层细胞向肝芽细胞阶段的分化过程中。A quinone bacterial metabolite; inhibits the growth of a variety of bacteria (MICs = P. falciparum (IC80 = 0.0033 µM); inhibits proliferation of HCT116, A549, and HL-60 cancer cells (IC50s = 0.4, 4.1, and 0.8 µM, respectively); promotes the differentiation of human iPS cells into hepatoblasts at the definitive endoderm cell-to-hepatoblast stage at 1 µM.分子式C16H14O6分子量302.3O=C1C2=C([C@@H](O[C@H](C2)CC(O)=O)C)C(C3=C(O)C=CC=C31)=O