Swertisin

一种具有多种生物活性的黄酮类C-糖苷；浓度为7.5µg/ml时可抑制HEK293中的SGLT2；是一种腺苷A1受体拮抗剂(IC50=137µM)；浓度为0.2-5µM时可抑制HepG2 2.2.15细胞中的HBV复制；降低链脲佐菌素诱发的糖尿病小鼠模型中的血糖水平；防止东莨菪碱诱发的小鼠Morris水迷宫逃逸潜伏期增加。A flavonoid C-glycoside with diverse biological activities; inhibits SGLT2 in HEK293 at 7.5 µg/ml; is an adenosine A1 receptor antagonist (IC50 = 137 µM); inhibits HBV replication in HepG2 2.2.15 cells at 0.2-5 µM; decreases blood glucose levels in a mouse model of streptozotocin-induced diabetes; prevents scopolamine-induced increases in escape latency in the Morris water maze in mice.分子式C22H22O10分子量446.4OC1=C2C(OC(C3=CC=C(C=C3)O)=CC2=O)=CC(OC)=C1[C@H]4[C@H](O)[C@H]([C@@H]([C@H](O4)CO)O)O