Ungeremine

一种具有多种生物活性的甜菜碱型生物碱；AChE的抑制剂（IC50=0.35µM）；拓扑异构酶-IIβ毒物；抑制人类拓扑异构酶I和-IIα以及大肠杆菌拓扑异构酶I和-IV对超螺旋DNA的松弛（IC50s分别为6.1、25.8、15和7.3µM）；抑制多种癌细胞的生长（IC50s=0.7-2.5µM）；对多种药物敏感和耐药癌细胞具有细胞毒性（IC50s分别为4.89-6.45和3.67-75.24µM）；诱导CCRF-CEM白血病细胞中的铁死亡、坏死性凋亡、凋亡和自噬；每周两次，每次60mg/kg，可降低GXF251L小鼠异种移植模型中的肿瘤生长。A betaine-type alkaloid with diverse biological activities; an inhibitor of AChE (IC50 = 0.35 µM); a topoisomerase-IIβ poison; inhibits the relaxation of supercoiled DNA by human topoisomerase I and -IIα and E. coli topoisomerase I and -IV (IC50s = 6.1, 25.8, 15, and 7.3 µM, respectively); inhibits the growth of a variety of cancer cells (IC50s = 0.7-2.5 µM); cytotoxic to a variety of drug-sensitive and -resistant cancer cells (IC50s = 4.89-6.45 and 3.67-75.24 µM, respectively); induces ferroptosis, necroptosis, apoptosis, and autophagy in CCRF-CEM leukemia cells; reduces tumor growth in a GXF251L mouse xenograft model at 60 mg/kg twice per week.分子式C16H12NO3分子量266.3OC1=CC2=C(C(CC3)=C1)[N+]3=CC4=CC5=C(OCO5)C=C24