DSR 6434

TLR7激动剂；诱导表达人类TLR7的HEK293细胞中的报告基因活性（EC50=7.9nM）；诱导从Tlr7野生型小鼠分离的脾细胞中产生CXCL10、IL-12p70、IFN-γ和TNF-α；在CT26小鼠结肠癌模型中缩小肿瘤体积、增加存活率，并增强电离辐射的抗肿瘤作用；在KHT小鼠纤维肉瘤模型中增强电离辐射的抗肿瘤作用并减少转移瘤数量。A TLR7 agonist; induces reporter gene activity in HEK293 cells expressing human TLR7 (EC50 = 7.9 nM); induces production of CXCL10, IL-12p70, IFN-γ, and TNF-α in splenocytes isolated from Tlr7 wild-type mice; reduces tumor volume and increases survival, as well as potentiates the antitumor effects of ionizing radiation, in a CT26 murine colon cancer model; potentiates the antitumor effects of ionizing radiation and decreases the number of metastases in a KHT murine fibrosarcoma model.分子式C19H28N8O2分子量400.5O=C1NC2=C(N)N=C(NCCCC)N=C2N1CC3=CN=C(OCCN(C)C)C=C3