Opicapone

COMT抑制剂；抑制大鼠肝脏（但不抑制脑）匀浆中的COMT活性（ED50=1.05mg/kg）；以3mg/kg与苄丝肼和L-DOPA联合使用时，可提高L-DOPA血浆水平并降低3-OMD血浆水平。A COMT inhibitor; inhibits COMT activity in rat liver, but not brain, homogenates (ED50 = 1.05 mg/kg); increases L-DOPA plasma levels and reduces 3-OMD plasma levels when administered in combination with benserazide and L-DOPA at 3 mg/kg.分子式C15H10Cl2N4O6分子量413.2OC1=CC(C2=NC(C(C(C)=C3Cl)=C([N](=O)=C3C)Cl)=NO2)=CC([N+]([O-])=O)=C1O