Loliolide

一种具有多种生物活性的单萜内酯；在无细胞测定中清除62.5-250µM的DPPH和过氧化物自由基；减少Vero细胞中过氧化物诱导的细胞凋亡；在10µg/ml时抑制LPS诱导的小鼠分离T细胞和B细胞增殖；降低Huh7.5细胞中的HCV传染性(EC50=2.48µM)；在10和50µM时抑制HCV与Huh7.5细胞的结合。A monoterpene lactone with diverse biological activities; scavenges DPPH and peroxide radicals in cell-free assays from 62.5-250 µM; reduces peroxide-induced apoptosis in Vero cells; inhibits LPS-induced proliferation of isolated mouse T and B cells at 10 µg/ml; reduces HCV infectivity in Huh7.5 cells (EC50 = 2.48 µM); inhibits HCV binding to Huh7.5 cells at 10 and 50 µM.分子式C11H16O3分子量196.2C[C@]12C(C(C)(C[C@@H](C1)O)C)=CC(O2)=O