Naringenin Chalcone

一种具有多种生物活性的黄酮类化合物，能够抑制SST和SST-T细胞的增殖，其IC₅₀值分别为92µg/ml和184µg/ml。此外，该化合物在TPA诱导的皮肤癌小鼠模型中，以50µg/动物的剂量给药，可减少乳头瘤的数量。在TPA诱导的炎症小鼠模型中，局部给药可减轻耳部水肿。在卵清蛋白诱导的过敏性哮喘小鼠模型中，以0.8mg/kg剂量给药可减少气道高反应性、支气管肺泡灌洗液中嗜酸性粒细胞的浸润以及肺部黏液的产生。这些结果表明，该黄酮类化合物在抗肿瘤、抗炎和抗过敏方面具有显著的药理活性，有望开发为新型药物。A flavonoid with diverse biological activities; inhibits the proliferation of SST and SST-T cells (IC50s = 92 and 184 µg/ml); reduces the number of papillomas in a mouse model of TPA-induced skin carcinogenesis at 50 µg/animal; topical administration reduces ear edema in a mouse model of TPA-induced inflammation; reduces airway hyperresponsiveness, BALF eosinophil infiltration, and lung mucus production in a mouse model of ovalbumin-induced allergic asthma at 0.8 mg/kg.分子式C15H12O5分子量272.3O=C(C1=C(O)C=C(O)C=C1O)C=CC2=CC=C(C=C2)O