TVB-3166

FASN抑制剂(IC50=0.042µM)；抑制Calu-6和MRC-5细胞中的棕榈酸生物合成；在0.2µM时诱导Calu-6和22Rv1细胞凋亡；在60mg/kg时降低OVCAR-8小鼠异种移植模型和K-Ras野生型或突变型PDX小鼠模型中的肿瘤生长；在50mg/kg时降低感染RSV-A的小鼠的肺病毒滴度。A FASN inhibitor (IC50 = 0.042 µM); inhibits palmitate biosynthesis in Calu-6 and MRC-5 cells; induces apoptosis in Calu-6 and 22Rv1 cells at 0.2 µM; reduces tumor growth in an OVCAR-8 mouse xenograft model and K-Ras-wild-type or -mutant PDX mouse models at 60 mg/kg; reduces lung viral titers in mice infected with RSV-A at 50 mg/kg.分子式C24H24N4O分子量384.5N#CC1=CC=C(C2CN(C2)C(C3=CC(C4=NNC(C)=C4C)=C(C)C=C3C)=O)C=C1