7-Methoxyflavone

一种黄酮；在无细胞测定中抑制芳香酶（IC50=1.9µM）；在20µM浓度下抑制RAW 264.7巨噬细胞中LPS诱导的NO生成17.74%；在报告测定中激活雄激素和/或糖皮质激素受体转录活性；在小鼠乙酸诱发的翻滚试验中具有抗伤害活性（ED50=82.5µmol/kg）。A flavone; inhibits aromatase in a cell-free assay (IC50 = 1.9 µM); inhibits LPS-induced NO production by 17.74% in RAW 264.7 macrophages at 20 µM; activates androgen and/or glucocorticoid receptor transcriptional activity in a reporter assay; has antinociceptive activity in the acetic acid-induced writhing test in mice (ED50 = 82.5 µmol/kg).分子式C16H12O3分子量252.3O=C1C=C(C2=CC=CC=C2)OC3=CC(OC)=CC=C13