Trapidil

PDGF诱导活性的抑制剂和抗血小板剂；抑制PDGF诱导的U251MG神经胶质瘤细胞和分离的大鼠主动脉平滑肌细胞增殖；在1mM浓度下抑制ADP、花生四烯酸或U-46619诱导的清洗分离人血小板中的血小板聚集；在以30mg/kg剂量喂食高胆固醇饮食的兔子中，减少内膜厚度的增加并防止球囊血管成形术引起的再狭窄。An inhibitor of PDGF-induced activity and an antiplatelet agent; inhibits PDGF-induced proliferation of U251MG glioma cells and isolated rat aortic smooth muscle cells; inhibits ADP-, arachidonic acid-, or U-46619-induced platelet aggregation in washed isolated human platelets at 1 mM; reduces increases in intimal thickness and prevents restenosis induced by balloon angioplasty in rabbits fed a high-cholesterol diet at 30 mg/kg.分子式C10H15N5分子量205.3CCN(CC)C1=CC(C)=NC2=NC=NN21