CP94

一种铁螯合剂；浓度为150µM时，与原卟啉IX前体ALA、MAL或HAL介导的PDT结合，可增强原卟啉IX的光漂白作用并降低A431细胞的存活率；浓度为2mg/ml时，可降低小鼠肝脏总非血红素和铁蛋白储存铁的水平，并升高肝脏原卟啉的水平；浓度为100mg/kg时，可降低二茂铁引起的大鼠脑铁水平升高。An iron chelator; enhances protoporphyrin IX photobleaching and decreases in the viability of A431 cells at 150 µM in combination with PDT mediated by the protoporphyrin IX precursors ALA, MAL, or HAL; decreases hepatic total non-heme and ferritin-stored iron levels, as well as increases hepatic protoporphyrin levels, in mice at 2 mg/ml in the drinking water; reduces ferrocene-induced increases in rat brain iron levels at 100 mg/kg.分子式C9H13NO2分子量167.2O=C1C=CN(CC)C(CC)=C1O