1-methyl-L-Tryptophan

IDO抑制剂(Ki=19µM)；在100µM浓度下，抑制原代人类单核细胞衍生的IDO阳性树突状细胞产生犬尿氨酸，并增加异基因MLR中的T细胞增殖；逆转卡介苗炎症诱发的抑郁模型中小鼠的抑郁样行为；增加异基因MLR中的T细胞增殖。An IDO inhibitor (Ki = 19 µM); inhibits kynurenine production from primary human monocyte-derived IDO-positive dendritic cells, and increases T cell proliferation, in an allo-MLR at 100 µM; reverses depressive-like behavior in mice in a Bacillus Calmette-Guerin inflammation-induced model of depression; increases T cell proliferation in an allo-MLR.分子式C12H14N2O2分子量218.3OC([C@@H](N)CC1=CN(C)C2=CC=CC=C12)=O