Asperosaponin VI

一种三萜皂苷；以浓度依赖性方式增加MC3T3-E1前成骨细胞中的BMP2水平并诱导其分化；在20mg/kg剂量下可减少胶原诱导性关节炎小鼠模型中的关节炎症和骨质流失；在150和450mg/kg剂量下可降低乙酸诱导的血管通透性增加并增加小鼠在热板测试中缩爪的潜伏期。A triterpenoid saponin; increases BMP2 levels in, and induces differentiation of, MC3T3-E1 preosteoblasts in a concentration-dependent manner; reduces joint inflammation and bone loss in a mouse model of collagen-induced arthritis at 20 mg/kg; reduces increases in acetic acid-induced vascular permeability and increases the latency to paw withdrawal in the hot plate test in mice at 150 and 450 mg/kg.分子式C47H76O18分子量929.1OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC[C@H]([C@H]([C@@H]([C@H]2O)O)O)O[C@H]2OC([C@]34[C@](CC(C)(CC4)C)([H])C5=CC[C@@]([C@@]6([C@@]([C@@](C)([C@H](CC6)O[C@H]7[C@@H]([C@H]([C@H](CO7)O)O)O)CO)([H])CC8)C)([H])[C@]8(C)[C@@]5(CC3)C)=O