Diprovocim-1

TLR1/TLR2激动剂；诱导THP-1细胞中的TNF-α释放(EC50=110pM)；增加对10mg/kg卵清蛋白致敏的野生型小鼠中卵清蛋白特异性IgG1的产生；增强抗PD-L1抗体诱导的细胞毒性T淋巴细胞活化，减少肿瘤生长，并增加B16/F10鼠黑色素瘤模型中的存活率。An agonist of TLR1/TLR2; induces TNF-α release in THP-1 cells (EC50 = 110 pM); increases the production of ovalbumin-specific IgG1 in wild-type mice sensitized to ovalbumin at 10 mg/kg; enhances anti-PD-L1 antibody-induced activation of cytotoxic T lymphocytes, reduction of tumor growth, and increases in survival in a B16/F10 murine melanoma model.分子式C56H56N6O6分子量909.1O=C(C1=CC=C(C=C1)C(N2C[C@@H](C(N[C@@H]3[C@](C4=CC=CC=C4)([H])C3)=O)[C@H](C(N[C@@H]5[C@](C6=CC=CC=C6)([H])C5)=O)C2)=O)N7C[C@@H](C(N[C@@H]8[C@](C9=CC=CC=C9)([H])C8)=O)[C@H](C(N[C@@H]%10[C@](C%11=CC=CC=C%11)([H])C%10)=O)C7