Saikosaponin D (hydrate)

一种具有多种生物活性的三萜皂苷；抑制5-20µM的SW1736、ARO和8305C间变性甲状腺癌细胞增殖并诱导其凋亡；在5、10和20mg/kg的剂量下减少ARO小鼠异种移植模型中的肿瘤重量和体积；逆转肠道微生物多样性的降低，减少结肠炎症细胞浸润、粘膜增厚和杯状细胞耗竭，并在DSS诱发的溃疡性结肠炎小鼠模型中增加结肠长度；具有抗抑郁样活性，并在1mg/kg的剂量下抑制小鼠LPS诱发的海马小胶质细胞活化。A triterpene saponin with diverse biological activities; inhibits the proliferation of, and induces apoptosis in, SW1736, ARO, and 8305C anaplastic thyroid cancer cells from 5-20 µM; reduces tumor weight and volume in an ARO mouse xenograft model at 5, 10, and 20 mg/kg; reverses reductions in gut microbial diversity, reduces colonic inflammatory cell infiltration, mucosal thickening, and goblet cell depletion, and increases colon length in a mouse model of DSS-induced ulcerative colitis; has antidepressant-like activity and inhibits LPS-induced hippocampal microglial activation in mice at 1 mg/kg.分子式C42H68O13 • XH2O分子量781C[C@]12[C@]3(C=C[C@@]4([H])[C@]2(CC[C@]5([H])[C@@]4(CC[C@@H]([C@@]5(C)CO)O[C@H]6[C@@H]([C@H]([C@H]([C@H](O6)C)O)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO)O)C)C)[C@@]8([H])[C@@]([C@@H](C1)O)(CCC(C)(C8)C)CO3.O