MPC-6827 (hydrochloride)

具有抗癌活性的微管蛋白聚合抑制剂；在无细胞测定中以0.5、5和50µM抑制微管蛋白聚合，在A549细胞中以10nM抑制微管蛋白聚合；诱导T47D、HCT116和SNU-398癌细胞凋亡（EC50s分别为2、3和2nM）；在2.5-10mg/kg剂量下降低各种小鼠异种移植模型中的肿瘤生长。An inhibitor of tubulin polymerization with anticancer activity; inhibits tubulin polymerization in a cell-free assay at 0.5, 5, and 50 µM, as well as in A549 cells at 10 nM; induces apoptosis in T47D, HCT116, and SNU-398 cancer cells (EC50s = 2, 3, and 2 nM, respectively); reduces tumor growth in various mouse xenograft models from 2.5-10 mg/kg.分子式C17H17N3O • HCl分子量315.8COC(C=C1)=CC=C1N(C)C2=C3C=CC=CC3=NC(C)=N2.Cl