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RSV融合抑制剂;可降低RSV感染的HeLa细胞中的RSV复制(IC50=0.5nM),CC50>50µM;在感染前以4-100mg/kg的剂量给药,可降低棉鼠RSV模型中灌洗肺组织中的RSV病毒滴度和肺中的病毒RNA生成;以每天5和25mg/kg的剂量给药,可降低新生羔羊RSV模型中BALF中的RSV病毒滴度。An RSV fusion inhibitor; reduces RSV replication in RSV-infected HeLa cells (IC50 = 0.5 nM) with a CC50 of >50 µM; reduces RSV viral titers in lavaged-lung tissue and viral RNA production in the lungs in a cotton rat RSV model at 4-100 mg/kg administered prior to infection; reduces RSV viral titers in BALF in a neonatal lamb RSV model at 5 and 25 mg/kg per day.分子式C21H20ClF3N4O3S分子量500.9O=C1N(CC2=CC3=C(N2CCCS(C)(=O)=O)C=CC(Cl)=C3)C4=C(N1CC(F)(F)F)C=CN=C4O=C1N(CC2=CC3=C(N2CCCS(C)(=O)=O)C=CC(Cl)=C3)C4=C(N1CC(F)(F)F)C=CN=C4
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文献和实验相关实验
Treatment of Infections Due to Resistant Staphylococcus aureus
, delafloxacin, and JNJ-Q2. Thus, there are currently many effective drugs to treat resistant S. aureus infections and many promising agents in the pipeline. Nevertheless, S. aureus remains a formidable adversary, and despite our deep bullpen of potential
Characterization of Histaminergic Receptors
H 4 Antagonists Thioperamide >100,000 >100,000 72.6 27 d Tocris Cookson JNJ7777140 c >10,000
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