Bimosiamose

泛选择素抑制剂（E-、P-和L-选择素的IC50分别为88、20和86µM）；在129µM时可降低HL-60细胞对E-和P-选择素的粘附；在200mg/kg剂量下可减少患者来源的异种移植小鼠银屑病模型中的皮肤鳞屑、硬结和红斑；降低严重肝缺血再灌注损伤大鼠模型中的肝脏ALT、AST、LDH和MPO水平并减少中性粒细胞浸润；预防线虫诱发的绵羊晚期气道反应性并降低哮喘小鼠模型中的气道高反应性。A pan-selectin inhibitor (IC50s = 88, 20, and 86 µM for E-, P-, and L-selectin, respectively); reduces adhesion of HL-60 cells to E- and P-selectin at 129 µM; reduces skin scaliness, induration, and erythema in a patient-derived xenograft mouse model of psoriasis at 200 mg/kg; decreases hepatic ALT, AST, LDH, and MPO levels and reduces neutrophil infiltration in a rat model of severe hepatic ischemia-reperfusion injury; prevents nematode-induced late airway reactivity in sheep and reduces airway hyperresponsiveness in a mouse model of asthma.分子式C46H54O16分子量862.9OC(CC1=CC=CC(C2=C(O[C@@H]3[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C=CC(CCCCCCC4=CC(C5=CC=CC(CC(O)=O)=C5)=C(O[C@@H]6[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)C=C4)=C2)=C1)=O