666-15

CREB介导的基因转录抑制剂（在基于细胞的报告基因检测中IC50=81nM）；抑制A549、MCF-7、MDA-MB-231和MDA-MB-468细胞的生长（GI50s分别为0.47、0.31、0.073和0.046μM）；以每天10mg/kg、每周五天的剂量服用，可降低MDA-MB-468小鼠异种移植模型中的肿瘤生长。An inhibitor of CREB-mediated gene transcription (IC50 = 81 nM in a cell-based reporter assay); inhibits the growth of A549, MCF-7, MDA-MB-231, and MDA-MB-468 cells (GI50s = 0.47, 0.31, 0.073, and 0.046 μM, respectively); reduces tumor growth in an MDA-MB-468 mouse xenograft model at 10 mg/kg per day, five days per week.分子式C33H30ClN3O5 • HCl分子量620.5O=C(NCCOC1=CC(C=CC=C2)=C2C=C1C(NC3=C(O)C=C(Cl)C=C3)=O)C4=CC(C=CC=C5)=C5C=C4OCCCN.Cl