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- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
FCCP
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
370-86-5
- 规格：
100mg/50mg/5mg/1mg/10mg
| 规格： | 100mg | 产品价格： | ￥3490.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥2090.0 |
| 规格： | 5mg | 产品价格： | ￥334.0 |
| 规格： | 1mg | 产品价格： | ￥140.0 |
| 规格： | 10mg | 产品价格： | ￥540.0 |
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy
成员:Jialong Liu, Chao Feng, Ruzhou Zhao, Hongbin Song, Linfei Huang, Nan Jiang, Xiaopan Yang, Lanlan Liu, Cuijuan Duan, Luming Wan, Qi Gao, Lijuan Sun, Xufeng Hou, Muyi Liu, Yanhong Zhang, Xuemiao Zhang, Dandan Zhang, Yufei Wang, Yong Li, Xueping Ma, Hui Zhon
论文因子:10.3 发表期刊:Journal for ImmunoTherapy of Cancer pmid:39762082
| 基本信息 | |
| CAS | No.370-86-5 |
| 英文名称 | FCCP |
| 别名 | Trifluoromethoxy carbonylcyanide phenylhydrazone;Carbonyl cyanide 4-(trifluoromethoxyphenyl)hydrazone;Trifluoromethoxy carbonylcyanide phenylhydrazoneCarbonyl cyanide 4-(trifluoromethoxyphenyl)hydrazone;FCCP |
| 分子式 | C10H5F3N4O |
| 分子量 | 254.17 |
| 溶解性 | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| 纯度 | ≥98% |
| 外观(性状) | Light yellow to yellow Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 206-730-8 |
| MDL | MFCD00009699 |
| SMILES | N#C/C(C#N)=N/NC1=CC=C(OC(F)(F)F)C=C1 |
| InChIKey | BMZRVOVNUMQTIN-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H |
| PubChem CID | 3330 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | FCCP在线粒体中是一种有效的氧化磷酸化的解偶联剂,通过转运质子破坏ATP的合成。 |
| 生物活性 | FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1]. |
| In Vitro | Because it has been suggested that catabolic processing of the APP holoprotein occurs in acidic intracellular compartments， we studied the effects of the protonophore carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone (FCCP) and the H+-ATPase inhibitor bafilomycin A1 on APP catabolism in human embryonic kidney 293 cells expressing either wild-type or 'Swedish' mutant APP. Unlike bafilomycin A1， which inhibits beta-amyloid production in cells expressing mutant but not wild-type APP， FCCP inhibited beta-amyloid production in both cell types. Moreover， the effects of FCCP were independent of alterations in total cellular APP levels or APP maturation， and the concentrations used did not alter either cellular ATP levels or cell viability. Bafilomycin A1， which had no effect on beta-amyloid production in wild-type cells， inhibited endocytosis of fluorescent transferrin， whereas concentrations of FCCP that inhibited beta-amyloid production in these cells had no effect on endosomal function. Thus， in wild-type-expressing cells it appears that the beta-amyloid peptide is not produced in the classically defined endosome. Although bafilomycin A1 decreased beta-amyloid release from cells expressing mutant APP but not wild-type APP， it altered lysosomal function in both cell types， suggesting that in normal cells beta-amyloid is not produced in the lysosome. [1] |
| 细胞实验 | K695sw cells are maintained and exposed to vehicle or various concentrations of FCCP as mentioned above with the exception that cells are plated at a density of 20，000 cells per well in 96-well plates. Twenty-four hours after plating， cells are exposed to various treatments in Dulbeccos modified Eagles medium supplemented with sodium pyruvate (1 mM). At the same time as drug exposures， YO-PRO (4 μM) is added to each well， and its uptake is quantified every 30 min for 1 day at 37°C using a Cytofluor 2350 fluorometric plate reader. As a positive control， all wells are exposed to 0.1% Triton X-100 at the end of the experiment[1]. |
| 数据来源文献 | [1]. Connop BP et al.Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. J Neurochem. 1999 Apr;72(4):1457-65. [2]. Tanpradit N， et al. Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) pre-exposure ensures follicle integrity during in vitro culture of ovarian tissue but not during cryopreservation in the domestic cat model. J Assist Reprod Genet. 2016 Dec;33(12):1621-1631. Epub 2016 Sep 17. [3]. Kondapalli C， et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2(5):120080. |
| 单位 | 瓶 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy
成员:Jialong Liu, Chao Feng, Ruzhou Zhao, Hongbin Song, Linfei Huang, Nan Jiang, Xiaopan Yang, Lanlan Liu, Cuijuan Duan, Luming Wan, Qi Gao, Lijuan Sun, Xufeng Hou, Muyi Liu, Yanhong Zhang, Xuemiao Zhang, Dandan Zhang, Yufei Wang, Yong Li, Xueping Ma, Hui Zhon
论文因子:10.3 发表期刊:Journal for ImmunoTherapy of Cancer pmid:39762082
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