IG1340 β-甘油磷酸钠五水合物 代谢酶/蛋白酶 索莱宝

可以为成骨细胞提供磷酸离子，同时促进生理性钙盐的沉积和钙化，是骨髓基质干细胞产生矿化结节的必要条件。可促进地塞米松对干细胞的诱导分化。    

使用本产品的应用案例（仅供参考）

In Vitro

Cell（Osteogenic/成骨诱导；10 mM β-glycerophosphate）

The osteogenic medium was the complete culture medium supplemented with 10 nM dexamethasone(Solarbio), 10 mM β-glycerophosphate (Solarbio), and 50 mg/l ascorbic acid (Solarbio). 

数据来源文献：Jia L, Zhang Y, Ji Y, Li X, Xing Y, Wen Y, Huang H, Xu X. Comparative analysis of lncRNA and mRNA expression profiles between periodontal ligament stem cells and gingival mesenchymal stem cells. Gene. 2019 May 30;699:155-164. doi: 10.1016/j.gene.2019.03.015. Epub 2019 Mar 12. PMID: 30876821.

Cell（Osteogenic/成骨诱导；10 mM β-glycerophosphate）

Osteogenic induced medium contained complete culture medium supplemented with 100 nM dexamethasone (Solarbio, Beijing, China), 10 mM β-glycerophosphate (Solarbio) and 50 mg/l ascorbic acid (Solarbio).  The medium was replaced every other day.  Alizarin Red–positive mineralized matrix was used to evaluate osteogenic capacity by Alizarin red (AR) staining.

数据来源文献：Zhao Y, Liu H, Xi X, Chen S, Liu D. TRIM16 protects human periodontal ligament stem cells from oxidative stress-induced damage via activation of PICOT. Exp Cell Res. 2020 Dec 1;397(1):112336. doi: 10.1016/j.yexcr.2020.112336. Epub 2020 Oct 19. PMID: 33091421.

Cell（成骨分化实验，人牙周膜干细胞（PDLSCs），β-glycerophosphate (10 mM)，7 days induction）

Cells were cultured in 24-well microtiter plates and induced to differentiate with mineralization induction medium, which was composed of α-MEM medium, 10 % FBS, β-glycerophosphate (10 mM), ascorbic acid (50 μM), and dexamethasone (0.1 μM). The medium was changed every 3 days. After 7 days induction, alkaline phosphatase (ALP) staining was performed. Alizarin red (AR) staining and semi-quantitative analysis were performed after 21 days.

来源：Liu X , Zhang H , Xu L ,et al.cGAMP-targeting injectable hydrogel system promotes periodontal restoration by alleviating cGAS-STING pathway activation[J].Bioactive Materials, 2025, 48(000):55-70.DOI:10.1016/j.bioactmat.2025.02.010.

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标题:Effect of 1α. 25-dihydroxyvitamin D3 on the osteogenic differentiation of human periodontal ligament stem cells and the underlying regulatory mechanism

成员:Ji Y. Zhang P. Xing Y. Jia L. Zhang Y. Jia T. Wu X

论文因子:3.818 发表期刊:Int J Mol Med pmid:30365053

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标题:Comparative analysis of lncRNA and mRNA expression profiles between periodontal ligament stem cells and gingival mesenchymal stem cells

成员:Jia L. Zhang Y. Ji Y. Li X. Xing Y. Wen Y. Huang H

论文因子:3.473 发表期刊:Gene pmid:30876821

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标题:Microarray analysis of long non-coding RNAs related to osteogenic differentiation of human dental pulp stem cells

成员:Hao X. Li D. Zhang D. Jia L.

论文因子:1.514 发表期刊:J Dent Sci pmid:35756759

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标题:Differential expression profiles of long noncoding RNAs and mRNAs in human bone marrow mesenchymal stem cells after exposure to a high dosage of dexamethasone

成员:Li T. Xu Y. Wang Y. Jiang Y

论文因子:5.081 发表期刊:Stem Cell Res Ther pmid:33407832

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标题:N-acetylcysteine regulates dental follicle stem cell osteogenesis and alveolar bone repair via ROS scavenging

成员:Meng Z;Liu J;Feng Z;Guo S;Wang M;Wang Z;Li Z;Li H;

论文因子:8.079 发表期刊:Stem Cell Res Ther pmid:36076278

基本信息
CAS	No.13408-09-8
中文名称	β-甘油磷酸钠五水合物
英文名称	β-Glycerophosphate Sodium Salt Hydrate
别名	五水β-甘油磷酸钠(二钠五水合物);β-Sodium glycerophosphate
分子式	C3H7Na2O6P·5H2O
分子量	306.11
溶解性	Soluble in Water ≥500mg/mL
纯度	≥98%
外观(性状)	White to off-white Solid
储存条件	Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
EC	EINECS 212-464-3
MDL	MFCD00002135
SMILES	OCC(OP(O[Na])(O[Na])=O)CO.[5H2O]
靶点	Phosphatase
通路	Metabolic Enzyme&Protease
背景说明	β-Glycerophosphate Sodium Salt Hydrate是一种磷酸酶 (phosphatase) 抑制剂。
单位	瓶