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- 详细信息
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Sodium Picosulfate
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
10040-45-6
- 规格：
5mg/10mg/25mg/50mg/100mg
| 规格： | 5mg | 产品价格： | ￥90.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥150.0 |
| 规格： | 25mg | 产品价格： | ￥330.0 |
| 规格： | 50mg | 产品价格： | ￥530.0 |
| 规格： | 100mg | 产品价格： | ￥862.0 |
| 基本信息 | |
| CAS | No.10040-45-6 |
| 中文名称 | 匹克硫酸钠 |
| 英文名称 | Sodium Picosulfate |
| 别名 | ;匹克硫酸钠;4，4-(吡啶-2-基亚甲基)双苯基双硫酸酯钠盐;吡苯氧磺钠;匹可硫酸钠;匹可硫酸钠(匹可速发);XMD892.; |
| 分子式 | C18H13NNa2O8S2 |
| 分子量 | 481.407 |
| 溶解性 | Soluble in DMSO |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 233-120-9 |
| MDL | MFCD03427264 |
| SMILES | C1=CC=NC(=C1)C(C2=CC=C(C=C2)OS(=O)(=O)[O-])C3=CC=C(C=C3)OS(=O)(=O)[O-].[Na+].[Na+] |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | Sodium Picosulfate可以抑制水和电解质类的吸收并增加它们的分泌,可用于泻药方向的相关研究。 |
| 生物活性 | Sodium Picosulfate inhibits absorption of water and electrolytes， and increases their secretion.[1-4] |
| In Vitro | Sodium Picosulfate displays cytotoxic effects on cultured liver cells. 800 and 1600 mg/mL induces dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values of the rapidly growing cultured liver cells of rabbit. Comparable but less severe effects are observed in 4-day old liver cell cultures of rat，while liver cells cultured for 6 to 11 days tolerate 1600 mg/mL Sodium Picosulfate. In human liver cultures the number of cells is slightly lowered at 800 and 1600 mg/mL and the number of nuclei in division is decreased dependent on dose. [1] |
| 细胞实验 | Sodium Picosulphate treatment for long-term has no effects on neuropeptide content of the rat colon. Over a 6-month period，daily doses(10 mg/kg/day)or twice-weekly doses(7.5 mg/kg/day)of Sodium Picosulphate do not affect the level of Vasoactive intestinal polypeptide(VIP)，somatostatin，and substance P in mucosa，submucosa，or muscularis externa. [2] Sodium Picosulphate has no major influence on ileal and colonic epithelial cell proliferation. In a 12 weeks study，10 mg/kg Sodium Picosulphate continuously treatment does not influence the labeling index of Brdu(LI)in the ileum and induces no statistically significant increase of the LI when the treated groups are compared with the control group. The proliferative pattern along the crypts remains unchanged with sodium picosulphate treatment throughout the study. [3] Sodium Picosulphate does not induce chronic changes in colonic motility in rats under long-term treatment. 10 mg/kg/day Sodium Picosulphate pretreated for 23 weeks does not induce any significant change in the duration of long spike bursts(LSB)which are associated with phasic contractions，or in LSB frequency in the fasted state or after a 3-gram meal. [4] |
| 细胞实验 | Ceco-colonic myoelectrical activity was investigated in rats pretreated for 23 weeks by sennosides(10 or 40 mg/kg/day)，Na-picosulfate(2.5 or 10 mg/kg/day)or laxative vehicle(control). On the last week of treatment the animals were equipped with Nichrome electrodes on the cecum，the proximal and distal colon. In comparison with controls，sennoside or Na-picosulfate treatment did not induce any significant(p > 0.05)change in the duration of long spike bursts(LSB)which are associated with phasic contractions. On the last 2 days of treatment the frequency of LSB for 2 h before and 2 h after laxative administration，as well as for 30 min after a 3-gram meal was not significantly(p > 0.05)different in control and treated animals. Similarly，on the first 2 days，as well as on days 13 and 14，after the end of treatment，no significant(p > 0.05)difference in the LSB frequency appeared between control and treated animals，in the fasted state or after a 3-gram meal.[2] |
| 动物实验 | The effect of sodium picosulfate was examined in liver cell cultures of rabbit，rat and man exposed to substance concentrations of 25，50，100，200，400，800 and 1600 micrograms/ml. At 400，800 and 1600 micrograms/ml the rapidly growing cultured liver cells of rabbit showed dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values in the medium at 800 and 1600 micrograms/ml. Comparable but less severe effects were observed in 4-day old liver cell cultures of rat，while liver cells cultured for 6 to 11 days tolerated 1600 micrograms/ml sodium picosulfate. In human liver cultures the number of cells was slightly lowered at 800 and 1600 micrograms/ml and the number of nuclei in division was decreased dependent on dose.[1] |
| 数据来源文献 | [1]. Nishikawa J， et al. Arzneimittelforschung， 1981， 31(2)， 321-325. [2]. Tzavella K， et al. Eur J Gastroenterol Hepatol， 1995， 7(1)， 13-20. [3]. Geboes K， et al. Pharmacology， 1993， 47 Suppl 1， 187-195. [4]. Fioramonti J， et al. Pharmacology， 1993， 47 Suppl 1， 155-161. |
| 单位 | 瓶 |
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IS2930 匹克硫酸钠 抑制剂/拮抗剂/激动剂 索莱宝
￥90 - 862
