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- 详细信息
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Oxyphenisatin Acetate
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
115-33-3
- 规格：
25mg/50mg/100mg/5mg/10mg/500mg
| 规格： | 25mg | 产品价格： | ￥482.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥676.0 |
| 规格： | 100mg | 产品价格： | ￥988.0 |
| 规格： | 5mg | 产品价格： | ￥182.0 |
| 规格： | 10mg | 产品价格： | ￥300.0 |
| 规格： | 500mg | 产品价格： | ￥2478.0 |
| 基本信息 | |
| CAS | No.115-33-3 |
| 中文名称 | 双醋酚丁 |
| 英文名称 | Oxyphenisatin Acetate |
| 别名 | 双醋酚丁;Izafenin;Diphesatine;Brocatine; |
| 分子式 | C24H19NO5 |
| 分子量 | 401.41 |
| 溶解性 | Soluble in DMSO |
| 纯度 | ≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 204-083-6 |
| MDL | MFCD00022793 |
| SMILES | CC(=O)OC1=CC=C(C=C1)C2(C3=CC=CC=C3NC2=O)C4=CC=C(C=C4)OC(=O)C |
| InChIKey | PHPUXYRXPHEJDF-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H19NO5/c1-15(26)29-19-11-7-17(8-12-19)24(18-9-13-20(14-10-18)30-16(2)27)21-5-3-4-6-22(21)25-23(24)28/h3-14H,1-2H3,(H,25,28) |
| PubChem CID | 8269 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | Oxyphenisatin Acetate是一种具有生物活性或化学活性的化合物。 |
| 生物活性 | Oxphenisatin Acetate inhibits the growth of breast cancer cells by inhibiting translation, rapid phosphorylation. The pathways involved in apoptosis induction, starvation responses, and RNA/protein metabolism. Oxphenisatin Acetate also results in mitochondrial dysfunction.[1] |
| In Vitro | Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7，T47D，HS578T，and MDA-MB-468. In the estrogen receptor(ER)positive MCF7 and T47D cells，oxyphenisatin acetate induces TNFα expression and TNFR1 degradation，indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction[1].In the estrogen receptor(ER)positive MCF7 and T47D cells，OXY induced TNFα expression and TNFR1 degradation，indicating autocrine receptor-mediated apoptosis in these lines. Lastly，in an MCF7 xenograft model，OXY delivered intraperitoneally inhibited tumor growth，accompanied by phosphorylation of eIF2α and degradation of TNFR1. OXY induces a multifaceted cell starvation response，which ultimately induces programmed cell death[1]. |
| 细胞实验 | Oxyphenisatin acetate(300 mg/kg，i.p.)delivers intraperitoneally inhibited tumor growth，accompanied by phosphorylation of eIF2α and degradation of TNFR1 in an MCF7 xenograft model[1]. |
| 细胞实验 | Total RNA was isolated from MCF7 cells treated with 10 μmol/L OXY for 24 h and the microarray procedure performed as described previously using the GeneChip Human U133 plus 2.0 array . Pairwise analysis was performed on control versus treated arrays using a fivefold change cutoff，<0.01 adjusted P-value，GC-RMA normalization with Benjamini–Hochberg false discovery estimation[1]. |
| 动物实验 | Assessment in several other tumor models demonstrates tolerability with oxyphenisatin acetate at 300 mg/kg given once daily or 200 mg/kg given twice daily. For the MCF-7 study treatments are administered on an exact body weight basis using dose volumes of 1-2 mL/kg body weight. The vehicle control receives 100% DMSO. The treated group receives 300 mg/kg oxyphenisatin acetate once daily for a total of 10 days，followed by a 3 day rest and an additional 6 days of dosing. The dose solutions are prepared in 100% DMSO，aliquoted and stored frozen until used. The mice are monitored for a total of 52 days with treatment initiation occurring on day 27 posttumor implantation[1]. |
| 数据来源文献 | [1]. Morrison BL， et al. Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy， mitochondrial dysfunction， and autocrine TNFα-mediated apoptosis. Cancer Med. 2013 Oct;2(5):687-700. |
| 单位 | 瓶 |
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IO1290 双醋酚丁 抑制剂/拮抗剂/激动剂 索莱宝
￥182 - 2478
