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- 文献和实验
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Adenosine 5’-Diphosphate
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- CAS号：
58-64-0
- 规格：
50mg/100mg/250mg
| 规格： | 50mg | 产品价格： | ¥248.00 |
|---|---|---|---|
| 规格： | 100mg | 产品价格： | ¥400.00 |
| 规格： | 250mg | 产品价格： | ¥880.00 |
| CAS | 58-64-0 |
| 中文名称 | 腺苷-5'-二磷酸 |
| 英文名称 | Adenosine 5’-Diphosphate |
| 别名 | Adenosine diphosphate;adenosine pyrophosphate;ADP |
| 分子式 | C10H15N5O10P2 |
| 分子量 | 427.2 |
| 规格 | 100mg ; 250mg ; 50mg |
| 溶解性 | Soluble in Water ≥10mg/mL |
| 纯度 | HPLC≥98% |
| 级别 | Cell Culture |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| 运输条件 | 冷冻运输 |
| EC | EINECS 200-392-5 |
| MDL | MFCD00066473 |
| SMILES | O=P(O)(OP(O)(OC[C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O)=O)O |
| InChIKey | XTWYTFMLZFPYCI-KQYNXXCUSA-N |
| InChI | InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 |
| PubChem CID | 6022 |
| Beilstein Number | 67722 |
| 靶点 | Others |
| 通路 | Others |
| 背景说明 | 是一种含有两个磷酸基团的腺嘌呤核苷酸,具有生物或化学活性。 |
| 生物活性 | Adenosine diphosphate is an adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.[1] |
| In Vitro | Platelet aggregation studies. Aggregation was measured at 37°C by a turbidimetric method in a dual-channel Payton aggregometer(Payton Associates，Scarborough，Ontario，Canada). A 450-μL aliquot of platelet suspension was stirred at 1，100 rpm and activated by addition of different agonists，in the presence or absence of A2P5P or A3P5P at varying concentrations and in the presence of human fibrinogen(0.8mg/mL)，in a final volume of 500 μL. The extent of aggregation was estimated quantitatively by measuring the maximum curve height above baseline level. ADP-induced shape change was determined turbidimetri_x0002_cally in the presence of 5 mmol/L ethylenediaminetetraacetic acid(EDTA).[2] |
| 激酶实验 | Measurement of adenylyl cyclase activity. A 450-μL aliquot of washed platelets was stirred at 1，100 rpm in an aggregometer cuvette，and the following reagents were added at 30-second intervals: 1 μmol/L PGE1，100 μmol/L A2P5P or A3P5P，and 5 μmol/L ADP or vehicle(Tyrode’s buffer containing no Ca21 or Mg21). One minute later，the reaction was stopped by addition of 50 μL of ice-cold 6.6 N perchloric acid. B10 cells grown in 6-well tissue culture clusters were first incubated in BSS supplemented with 10-4 mol/L IBMX for 10 minutes at 37°C. Forskolin(1 μmol/L)and/or nucleotides were added(final volume 1 mL per well)and incubation was continued for 5 minutes at 37°C，after which the incubation solution was removed by aspiration and the cells extracted in 10%(vol/vol)ice-cold 6.6 N perchloric acid. The same procedure was applied to Jurkat cells except that the incubation solution was eliminated by centrifuging each tube at 200g for 30 seconds before extracting the cells in perchloric acid. Perchloric acid extracts were centrifuged at 11，000g for 5 minutes to eliminate protein precipitate and cyclic AMP was isolated from the supernatants as described by Khym37 using a mixture of trioctylamine and freon(28/22，vol/vol). The upper aqueous phase was lyophilized and the dry residue dissolved in the buffer provided with the commercial radioimmunoassay kit for cyclic AMP [2] |
| 数据来源文献 | [1]. Li YH， Li XF， Liu JT， Wang H， Fan LL， Li J， Sun GP. PKM2， a potential target for regulating cancer. Gene. 2018 May 15. [2] Hechler B ， Leon C ， Vial C ， et al. The P2Y1 Receptor Is Necessary for Adenosine 5′-Diphosphate–Induced Platelet Aggregation[J]. Blood， 1998， 92(1):152-159. |
| 单位 | 瓶 |
| 表格1 | |*|1mg|5mg|10mg|$$|1mM|2.3408mL|11.7041mL|23.4082mL|$$|5mM|0.4682mL|2.3408mL|4.6816mL|$$|10mM|0.2341mL|1.1704mL|2.3408mL| |
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文献和实验使其他分子磷酸化进行能量转移以推动生物体内的各种需能反应和实现细胞的各种功能活动。因此，人们把ATP看作是细胞里的“能量通货”（图2）。 ATP还是合成生物体内许多重要物质的原料。可作为腺苷酸组分合成核糖核酸（RNA）和腺苷酸的衍生物（见核苷酸）；提供磷酸基以合成D-葡萄糖、D-果糖、D-甘露糖和D-核糖等糖类的一磷酸或二磷酸衍生物，合成磷酸胆碱以及对某些蛋白质的磷酸化；提供无机焦磷酸以合成某些焦磷酸衍生物，如由核糖-5-磷酸与ATP反应合成α-D－5＇-磷酸核糖-1＇-焦磷酸
以腺苷二磷酸葡萄糖（ ADPG）为葡萄糖的供体，是对葡糖聚合体，通过糖基（ glycosyl）转移而催化α－ 1， 4-糖苷键的延长作用的酶。 EC2． 4． 1． 21。此外， ADPG是通过葡糖 -1-磷酸 ATP→ ADPG＋ ppi的酶反应（葡糖 -1-磷酸腺苷酰转移酶（ EC2． 7． 7． 27）而形成。有与淀粉粒结合的颗粒性和可溶性二种。粳型（直链淀粉 20％，支链淀粉 80％）的玉米和水稻的合成酶是颗粒性的，在糯型种子（支链淀粉 100％）中，几乎全部活性
一年内两次叫停！康方CD73单抗又“悬”了，PD-1的黄金搭档还香吗？
’-Nucleotidase)，是由NT5E基因编码的一种细胞表面，是催化AMP形成胞外腺苷的主要酶 [1]。人CD73的基因位于染色体6q14-921。CD73的进化相当保守，人CD73的cDNA序列与鼠的cDNA序列有86%的同源性 [2]。人CD73前体蛋白由574个氨基酸残基组成。CD73分子N末端第1-26位氨基酸残基及C末端第550-574位氨基酸残基被剪切后，第27-549位氨基酸残基序列即为成熟CD73，形成1个分子量约为70 kDa亚单位，由两个亚单位构成具有生物活性的同质二聚体，亚基间通过非共价键连接
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