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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Atipamezole Hydrochloride
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
104075-48-1
- 规格：
50mg/25mg/5mg/1mg/10mg
| 规格： | 50mg | 产品价格： | ￥2203.0 |
|---|---|---|---|
| 规格： | 25mg | 产品价格： | ￥1370.0 |
| 规格： | 5mg | 产品价格： | ￥405.0 |
| 规格： | 1mg | 产品价格： | ￥190.0 |
| 规格： | 10mg | 产品价格： | ￥738.0 |
是α2-ADr受体拮抗剂。
【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Wogonoside preserves against ischemia/reperfusion-induced myocardial injury by suppression of apoptosis; inflammation; and fibrosis via modulating Nrf2/HO-1 pathway.
成员:Zhang B; Xu D.
论文因子:2.38 发表期刊:Immunopharmacol Immunotoxicol. pmid:35708282
| 基本信息 | |
| CAS | No.104075-48-1 |
| 中文名称 | 阿替美唑盐酸盐 |
| 英文名称 | Atipamezole Hydrochloride |
| 别名 | 阿替美唑盐酸盐;4-(2-乙基-2-茚满)咪唑盐酸盐;AtipamezoleHCL; |
| 分子式 | C14H16N2·HCl |
| 分子量 | 248.75 |
| 溶解性 | Soluble in Water/DMSO ≥1mg/mL |
| 纯度 | HPLC≥98% |
| 外观(性状) | White to off-white Solid |
| 储存条件 | Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 105-700-9 |
| MDL | MFCD06407819 |
| SMILES | CCC1(CC2=CC=CC=C2C1)C3=CN=CN3.Cl |
| 靶点 | Adrenergic Receptor |
| 通路 | Endocrinology & Hormones;GPCR & G Protein;Neuronal Signaling |
| 背景说明 | Atipamezole Hydrochloride是α2-ADr受体拮抗剂。 |
| 生物活性 | Atipamezole (MPV 1248) is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM[1]. |
| IC50 | Ki: 1.6 nM[1] |
| In Vitro | The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1， 5-HT2 and I2 bindings sites[1]. |
| 细胞实验 | Atipamezole is well tolerated in rodents. In anesthetized， normotensive rats， the cardiovascular effects of atipamezole (0.01–1 mg/kg， i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception， atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness， selective attention， planning， learning， and recall in experimental animals， but not necessarily on short-term working memory[1]. |
| 数据来源文献 | [1]. Pertovaara A， et al.Pharmacological properties， central nervous system effects， and potential therapeutic applicationsof atipamezole， a selective alpha2-adrenoceptor antagonist. CNS Drug Rev. 2005 Autumn;11(3):273-88. |
| 单位 | 瓶 |
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文献和实验【本资料源自公开渠道，如需（此处）屏蔽，请联系删除】
标题:Wogonoside preserves against ischemia/reperfusion-induced myocardial injury by suppression of apoptosis; inflammation; and fibrosis via modulating Nrf2/HO-1 pathway.
成员:Zhang B; Xu D.
论文因子:2.38 发表期刊:Immunopharmacol Immunotoxicol. pmid:35708282
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