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- Solarbio
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- IE1400
- 2025年07月23日
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- 详细信息
- 技术资料
- 保存条件：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 保质期：
Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
- 英文名：
Endoxifen Hydrochloride
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- CAS号：
1032008-74-4
- 规格：
5mg/1mg/10mg
| 规格： | 5mg | 产品价格： | ￥630.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥350.0 |
| 规格： | 10mg | 产品价格： | ￥840.0 |
是一种有效的选择性estrogen receptor拮抗剂。
| 基本信息 | |
| CAS | No.1032008-74-4 |
| 中文名称 | Z-因多昔芬盐酸盐 |
| 英文名称 | Endoxifen Hydrochloride |
| 别名 | EndoxifenHCl |
| 分子式 | C25H27NO2·HCl |
| 分子量 | 409.95 |
| 溶解性 | Soluble in DMSO |
| 纯度 | ≥98% |
| 外观(性状) | Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| SMILES | OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)\CC)C=C1.[H]Cl.[Z] |
| 靶点 | Estrogen Receptor/ERR |
| 通路 | Endocrinology & Hormones |
| 背景说明 | 是一种有效的选择性estrogen receptor拮抗剂。 |
| 生物活性 | Endoxifen inhibited the hERG channel protein trafficking to the plasma membrane in a concentration-dependent manner. Endoxifen inhibited the hERG current by direct channel blockage and by the disruption of channel trafficking to the plasma membrane in a concentration-dependent manner. [1] |
| In Vitro | Endoxifen inhibited hERG tail currents at -50mV in a concentration-dependent manner with IC50 values of 1.6μM. The steady-state activation curve of the hERG currents was shifted to the hyperpolarizing direction in the presence of endoxifen.The voltage-dependent inhibition of hERG currents by endoxifen increased steeply in the voltage range of channel activation. The inhibition by endoxifen displayed a shallow voltage dependence(δ=0.18)in the full activation voltage range. A fast application of endoxifen induced a reversible block of hERG tail currents during repolarization in a concentration-dependent manner，which suggested an interaction with the open state of the channel. Endoxifen also decreased the hERG current elicited by a 5s depolarizing pulse to +60mV to inactivate the hERG currents，suggesting an interaction with the activated(open and/or inactivated)states of the channels.[1] |
| 数据来源文献 | [1]. Chae YJ， et al. Endoxifen， the active metabolite of tamoxifen， inhibits cloned hERG potassium channels. Eur J Pharmacol. 2015 Apr 5;752:1-7. |
| 单位 | 瓶 |
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IE1400 Z-因多昔芬盐酸盐 内分泌学/激素 索莱宝
￥350 - 840
